Alireza Salami is currently a group leader at Wallenberg Center for Molecular Medicine (WCMM) and a Senior Researcher at the Aging Research Center (ARC). He completed his PhD in computational neuroscience in 2012 at Umeå University where he implemented various multivariate and multimodal techniques to address questions related to structural and functional brain changes in normal aging.
Alireza’s primary research interest concentrates on the brain basis of cognitive decline in old age. It is critical to find measurement tools that can predict future severe cognitive decline, such as the one typically observed in demented elderly people, as early as possible, before substantial irreversible damage has been caused to the brain. Alireza’s group uses advanced functional magnetic resonance imaging (fMRI) and positron emission tomography (PET) in order to explore the functional and molecular bases of cognitive decline in aging. The group is currently heavily involved in data collection of a large-scale population-based study (DYNAMIC) in which 180 individuals (20-80 years old) undergo extensive cognitive test battery as well as fMRI scanning along with dopamine D1 assessment with SCH23390 and PET.
Salami, A., Garrett, D., Wåhlin, A., Rieckmann, A., Papenberg, G., Karalija, N., Jonasson, L., Andersson, M., Karalija, N., Axelsson, J., Johansson, J., Riklund, K., Lövden, M., Lindenberger, U., Bäckman, L., Nyberg, L. (In press). Dopamine D2/3 binding potential modulates neural signatures of working memory in a load-dependent fashion, Journal of Neuroscience.
Salami, A., Avelar-Pereira, B., Garzón, B., Sitnikov, R., Kalpouzos, G. (2018) Functional coherence of striatal resting-state networks is modulated by striatal iron content. NeuroImage 183, 495-503.
Salami, A., Rieckmann, A., Andersson, M., Wåhlin, A., Karalija, N., Lövden, M., Lindenberger, U., Bäckman, L., Nyberg, L. (2018) Neurocognitive Profiles of older adults with working-memory dysfunction. Cerebral Cortex 28.7, 2525-2539.
Kaboodvand, N., Lövden, M., Lindenberger, U., Bäckman, L., Nyberg, L., Salami, A. (2018). The Retrosplenial Cortex: A Memory Gateway between the Cortical Default Mode Network and the Medial Temporal Lobe. Human Brain Mapping, 39 (5), 2020-2034.
Pereira, B., Bäckman, L., Wåhlin, A., Nyberg, L., Salami, A. Age-related differences in dynamic interactions among default mode, fronto-parietal control, and dorsal attention networks during resting-state and an interference resolution. Frontiers in Aging Neuroscience, 9, 152.
Salami, A., Wåhlin, A., Kaboodvand, N., Lundquist, A., Nyberg, L., 2016. Longitudinal evidence for dissociation of anterior and posterior MTL resting state connectivity in aging: Links to perfusion and memory. Cerebral Cortex, 26 (10), 3953-3963.
Salami, A., Pudas, S., Nyberg, L., 2014. Elevated hippocampal resting-state connectivity underlies deficient neurocognitive function in aging. Proceedings of the National Academy of Science (PNAS), 111(49), 654-659.
Salami, A., Rieckmann, A., Fischer, H., Bäckman, L., 2014. A multivariate analysis of age-related differences in functional networks supporting conflict resolution. NeuroImage, 86, 150-163.
Salami, A., Eriksson, J., Nyberg, L., 2012. Opposing effects of aging on large-scale brain systems for memory encoding and cognitive control. Journal of Neuroscience 32 (31), 10749-10757.
Salami, A., Eriksson, J., Nilsson, L.G., Nyberg, L., 2012. Age-related white matter microstructural differences partly mediate age-related decline in processing speed but not cognition. Biochim Biophys Acta 1822 (3), 408-415.