Biomarker signatures of the multimorbidity-frailty continuum: in pursuit of personalized medicine for older adults

PI: Davide Liborio Vetrano

Assistant Professor in Medicine

The overall goal of this project is to identify novel biomarkers predicting longitudinal trajectories of multimorbidity and their impact on frailty in older adults. The coexistence and interplay between multimorbidity (i.e., presence of multiple diseases in the same individual), and frailty (i.e., clinical syndrome characterized by reduced resilience to stressors) is responsible, to a large extent, for the clinical complexity observed in older individuals.

This project will be pursued by a multidisciplinary team of researchers from Karolinska Institutet, SciLife Lab and Catholic University of Rome, taking advantage of readily available data from the Swedish National Study on Aging and Care in Kungsholmen (SNAC-K).

Through this project, we want to contribute to the development of personalized approaches to the clinical management of older individuals with multimorbidity and frailty.