Shireen Sindi


PhD, Medicine, associated to ARC
+46 73 550 8703

shireen.sindi@ki.se
KI Profile page: http://ki.se/en/people/shisin

Shireen SindiShireen Sindi is a postdoctoral researcher at the Department of Neurobiology, Care Sciences and Society (NVS), at Karolinska Institutet, Aging Research Center and Division of Clinical Geriatrics. She completed her former studies at McGill University (Canada), where she completed a Bachelor’s degree in psychology, then pursued her Master’s and doctoral studies at McGill’s Integrated Program in Neuroscience. Her doctoral studies have focused on the associations between stress hormones, memory performance and hippocampal volume. The title of her thesis is ‘Determinants of Stress Reactivity and Memory Performance in Older Adults’.

Shireen is currently working with Professor Miia Kivipelto.  The following summarises her current research activities in different projects related to preventive interventions for dementia and their implementation, as well as dementia risk factors such as psychological and physiological stress, sleep and associated biomarkers:

  • Leader and Coordinator: Multimodal preventive trials for Alzheimer’s Disease: towards multinational strategies (MIND-AD) (http://www.mind-ad.eu/). The goal is to identify effective prevention strategies for dementia based on experiences/data from 5 ongoing European dementia prevention trials. For the first time, a pilot trial will test a multimodal preventive intervention among patients with prodromal Alzheimer’s disease.
  • Leader and Coordinator: Multimodal strategies to promote a healthy brain in aging: Innovative evidence-based tools (MULTI-MODE). The goal is to develop and commercialise innovative evidence-based eHealth tools for dementia risk prediction and multidomain lifestyle intervention to prevent cognitive impairment/dementia. The products are designed for usage by citizens and health professionals. (http://ki.se/en/nvs/eit-health-project-aims-to-prevent-dementia-by-developing-new-innovations)
  • Leader and Coordinator: Cortisol and Stress in Alzheimer’s Disease (Co-STAR). Investigation of stress-related clinical and biomarker profiles and their association with cognition/dementia and neuroimaging correlates, in a population of memory clinic patients at the Karolinska University Hospital (Huddinge) Memory Clinic (http://www.nordicbrainnetwork.com/?page_id=1077)
  • Leader and Coordinator: Multi-centre sleep study. The project combines four Nordic population-based studies (From Sweden and Finland) to assess the associations between sleep and dementia, cognition and MRI measures.
  • Conducting analyses & writing articles: The role of telomere length in the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER).
  • Conducting analyses & writing articles: The role of midlife work-related stress and dementia, cognition and MRI measures in the Cardiovascular Risk Factors, Aging and Incidence of Dementia study (CAIDE)

Selected publications

Sindi S, Johansson L, Skoog J, Mattsson A D, Sjöberg L, Wang H X, … & Kivipelto M. (2018). Sleep disturbances and later cognitive status: A multi-centre study. Sleep Medicine (in press).

Sindi S, Kareholt I, Solomon A, Hooshmand B, Soininen H, Kivipelto M. Midlife work-related stress is associated with late-life cognition. Journal of neurology 2017;264(9):1996-2002. doi: 10.1007/s00415-017-8571-3.

Sindi S, Kåreholt I, Spulber G, Soininen H, Kivipelto M, & Solomon A. Midlife Work-Related Stress is Associated with Late-Life Gray Matter Volume Atrophy. Journal of Alzheimer’s Disease Reports, (Preprint), 1-9.

Sindi S, Hagman G, Hakansson K, Kulmala J, Nilsen C, Kareholt I, Soininen H, Solomon A, Kivipelto M. Midlife Work-Related Stress Increases Dementia Risk in Later Life: The CAIDE 30-Year Study. The journals of gerontology Series B, Psychological sciences and social sciences 2016. doi: 10.1093/geronb/gbw043.

Sindi S, Ngandu T, Hovatta I, Kåreholt I, Antikainen R, …Kivipelto M, & Solomon A. (2017). Baseline telomere length and effects of a multidomain lifestyle intervention on cognition: the FINGER randomized controlled trial. Journal of Alzheimer’s Disease, 59(4), 1459-1470.

Sindi S, Mangialasche, F., & Kivipelto, M. (2015). Advances in the prevention of Alzheimer’s disease. F1000prime reports, 7.

Sindi S, Calov E, Fokkens J, Ngandu T, Soininen H, Tuomilehto J, & Kivipelto, M. (2015). The CAIDE Dementia Risk Score App: The development of an evidence-based mobile application to predict the risk of dementia. Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 1(3), 328-333.

Sindi S, Fiocco AJ, Juster RP, Lord C, Pruessner J, & Lupien SJ. (2014). Now you see it, now you don’t: testing environments modulate the association between hippocampal volume and cortisol levels in young and older adults. Hippocampus, 24(12), 1623-1632.

Sindi S, Fiocco A J, Juster R P, Pruessner J, & Lupien SJ. (2013). When we test, do we stress? Impact of the testing environment on cortisol secretion and memory performance in older adults. Psychoneuroendocrinology, 38(8), 1388-1396.

Sindi S, Juster R P, Wan N, Nair NPV, Ying Kin N, & Lupien SJ. (2012). Depressive symptoms, cortisol, and cognition during human aging: The role of negative aging perceptions. Stress, 15(2), 130-137.

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