Shireen Sindi


PhD, Medicine, associated to ARC
+46 73 550 8703

shireen.sindi@ki.se
KI Profile page: http://ki.se/en/people/shisin

Shireen SindiShireen Sindi is a postdoctoral researcher at the Department of Neurobiology, Care Sciences and Society (NVS), at Karolinska Institutet, Aging Research Center and Division of Clinical Geriatrics. She completed her former studies at McGill University (Canada), where she completed a Bachelor’s degree in psychology, then pursued her Master’s and doctoral studies at McGill’s Integrated Program in Neuroscience. Her doctoral studies have focused on the associations between stress hormones, memory performance and hippocampal volume. The title of her thesis is ‘Determinants of Stress Reactivity and Memory Performance in Older Adults’.

Shireen is currently working with Professor Miia Kivipelto.  The following summarises her current research activities in different projects related to preventive interventions for dementia and their implementation, as well as dementia risk factors such as psychological and physiological stress, sleep and associated biomarkers:

  • Leader and Coordinator: Multimodal preventive trials for Alzheimer’s Disease: towards multinational strategies (MIND-AD) (http://www.mind-ad.eu/). The goal is to identify effective prevention strategies for dementia based on experiences/data from 5 ongoing European dementia prevention trials. For the first time, a pilot trial will test a multimodal preventive intervention among patients with prodromal Alzheimer’s disease.
  • Leader and Coordinator: Multimodal strategies to promote a healthy brain in aging: Innovative evidence-based tools (MULTI-MODE). The goal is to develop and commercialise innovative evidence-based eHealth tools for dementia risk prediction and multidomain lifestyle intervention to prevent cognitive impairment/dementia. The products are designed for usage by citizens and health professionals. (http://ki.se/en/nvs/eit-health-project-aims-to-prevent-dementia-by-developing-new-innovations)
  • Leader and Coordinator: Cortisol and Stress in Alzheimer’s Disease (Co-STAR). Investigation of stress-related clinical and biomarker profiles and their association with cognition/dementia and neuroimaging correlates, in a population of memory clinic patients at the Karolinska University Hospital (Huddinge) Memory Clinic (http://www.nordicbrainnetwork.com/?page_id=1077)
  • Leader and Coordinator: Multi-centre sleep study. The project combines four Nordic population-based studies (From Sweden and Finland) to assess the associations between sleep and dementia, cognition and MRI measures.
  • Conducting analyses & writing articles: The role of telomere length in the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER).
  • Conducting analyses & writing articles: The role of midlife work-related stress and dementia, cognition and MRI measures in the Cardiovascular Risk Factors, Aging and Incidence of Dementia study (CAIDE)

Selected publications

Sindi, S., Håkansson K., Hagman, G., Kulmala, J., Kåreholt, I., Soininen, H., Solomon, A., Kivipelto, M. (2016) Mid-life work-related stress increases dementia risk in late-life: The CAIDE 30-year study.  The Journals of Gerontology, Series B, gbw043.

Sindi, S., Calov, E., Fokkens, J., Ngandu, T., Soininen, H., Tuomilehto, J., Kivipelto, M.  (2015). The CAIDE Dementia Risk Score App: The development of an evidence-based mobile application to predict the risk of dementia. Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring. 1, 328-333.

Sindi, S., Mangialasche, F., Kivipelto, M. Advances in the prevention of Alzheimer’s disease (2015, May). F1000 Prime Reviews.

Feigin, V., Norrving, B., Kivipelto, M., Sindi, S. et al. New Strategy to Reduce the Global Burden of Stroke (2015).  Stroke 46:1740-1747.

Hampel H., Schneider, L., Ezio Giacobini, E., Kivipelto, M., Sindi S., Dubois, B., Broich, K., Nisticò, R., Aisen, P.S., Lista, S  (2015). Advances in the therapy of Alzheimer’s disease: targeting amyloid beta and tau and perspectives for the future. Expert Review of Neurotherapeutics, 15(1), 83-105.

Parmar, P., Krishnamurthi, R., Ikram, A., Norrving, Bo, Kivipelto, M., Sindi, S., Feigin, Valery et al (2015). The Stroke RiskometerTM App: Validation of a data collection tool and stroke risk predictor. International Journal of Stroke. 10(2):231-44.

GBD 2013 DALYs and HALE Collaborators, Murray CJ, Kivipelto M, Sindi, S. et al. (2015) Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. The Lancet 386(10010):2287–2323.

GBD 2013 DALYs and HALE Collaborators, Murray CJ, Kivipelto M, Sindi, S. et al. (2015). Global, regional, and national disability-adjusted life years (DALYs) for 306 diseases and injuries and healthy life expectancy (HALE) for 188 countries, 1990-2013: quantifying the epidemiological transition. The Lancet. Aug 27. pii: S0140-6736(15)61340-X

Sindi, S., Fiocco, A. J., Juster, R. P., Lord, C., Pruessner, J., Lupien, S. J. (2014) Now You See It, Now You Don’t: Testing Environments Modulate the Association Between Hippocampal Volume and Cortisol Levels in Young and Older Adults. Hippocampus, 24 (12), 1623-1632.

Sindi, S., Fiocco, A. J., Juster, R. P., Pruessner, J. C., Lupien, S. J. (2013) When we test, do we stress? Impact of the testing environment on cortisol secretion and memory performance in older adults. Psychoneuroendocrinology. 38 (8), 1388-1396.

Sindi, S., Juster, R.-P., Wan, N., Nair, N.P.V., Ng, F., Lupien, S.J. (2011) Internalization of negative aging perceptions is associated with depressive symptoms in healthy older adults, Stress, 15(2):130-7.

Nery de Souza-Talarico, J. Marin, M.F., Sindi, S., Lupien, S. J. (2011) Effects of stress hormones on the brain and cognition: evidences from normal to pathological aging. Dementia & Neuropsychologia, 5(1).

Marin, M.F., Lord, C., Andrews, J., Juster, R.P., Sindi, S., Arsenault-Lapierre, G., Fiocco, A.J., & Lupien, S.J. (2011) Chronic stress, cognitive function and mental health. Neurobiology of Learning and Memory, Special Issue on Memory Impairment and Disease 96(4), 583-595.

Juster, R. P., Sindi, S., Marin, M. F., Perna, A., Hashemi, A., Pruessner, J. C., Lupien, S. J. (2011) A clinical allostatic load index detects burnout physiology and symptomatology. Psychoneuroendocrinology, 36(6), 797-805.

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