Francesca Mangialasche


PhD, Medicine


francesca.mangialasche@ki.se
KI Profile page: http://ki.se/en/people/framan

Francesca Mangialasche
Photo: Giampaolo Sauchella

Francesca Mangialasche is a medical doctor, specialized in Geriatrics, with a PhD in Medical Science. Her research activity is based on a scientific collaboration between the Aging Research Center, Center for Alzheimer Research, Karolinska Institutet/Stockholm University; the Institute of Gerontology and Geriatrics, University of Perugia, Italy; the Finnish National Institute for Health and Welfare, Helsinki; and the Department of Neurology, University of Eastern Finland (Kuopio campus).

Her research focuses on clinical and neuropsychological aspects of brain aging and dementia, and on biological studies of brain aging with a specific emphasis on blood-based markers, and Oxidative/Nitrosative Stress and Antioxidants in Dementia/Alzheimer´s disease in elderly people. Francesca also collaborates with research projects studying multimorbidity in the elderly.

Francesca is a member of the Nordic Brain Network (NBN, www.nordicbrainnetwork.com), an international and multidisciplinary research group and collaborative forum lead by Professor Miia Kivipelto. The NBN conducts several studies on Alzheimer´s disease and dementia with a translational approach. Main preventive trials done by the group include FINGER (Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability) and MIND-AD (Multimodal preventive trials for Alzheimer’s disease, www.mind-ad.eu), which are at the forefront of international efforts to develop intervention strategies to prevent or delay the onset of cognitive impairment and Alzheimer´s disease.

Francesca is a co-founder of the European Dementia Prevention Initiative EDPI (www.edpi.org), an international collaboration aiming to improve preventive strategies against dementia and Alzheimer´s disease. Within EDPI, she collaborates in the Healthy Aging Through Internet Counselling in the Elderly trial (HATICE, www.hatice.eu)

Selected publications

Hooshmand B, Mangialasche F, Kalpouzos G, Solomon A, Kåreholt I, Smith AD, Refsum H, Wang R, Mühlmann M, Ertl-Wagner B, Laukka EJ, Bäckman L, Fratiglioni L, Kivipelto M. Association of Vitamin B12, Folate, and Sulfur Amino Acids With Brain Magnetic Resonance Imaging Measures in Older Adults: A Longitudinal Population-Based Study. JAMA Psychiatry. 2016 Jun 1;73(6):606-13.

Papenberg G, Ferencz B, Mangialasche F, Mecocci P, Cecchetti R, Kalpouzos G, Fratiglioni L, Bäckman L. Physical activity and inflammation: effects on gray-matter volume and cognitive decline in aging. Hum Brain Mapp. 2016 May 9. doi: 10.1002/hbm.23252.

Winblad B, Amouyel P, Andrieu S, Ballard C, Brayne C, Brodaty H, Cedazo-Minguez A, Dubois B, Edvardsson D, Feldman H, Fratiglioni L, Frisoni GB, Gauthier S, Georges J, Graff C, Iqbal K, Jessen F, Johansson G, Jönsson L, Kivipelto M, Knapp M, Mangialasche F, Melis R, Nordberg A, Rikkert MO, Qiu C, Sakmar TP, Scheltens P, Schneider LS, Sperling R, Tjernberg LO, Waldemar G, Wimo A, Zetterberg H. Defeating Alzheimer’s disease and other dementias: a priority for European science and society. Lancet Neurol. 2016 Apr;15(5):455-532.

Richard E, Jongstra S, Soininen H, Brayne C, Moll van Charante EP, Meiller Y, van der Groep B, Beishuizen CR, Mangialasche F, Barbera M, Ngandu T, Coley N, Guillemont J, Savy S, Dijkgraaf MG, Peters RJ, van Gool WA, Kivipelto M, Andrieu S. Healthy Ageing Through Internet Counselling in the Elderly: the HATICE randomised controlled trial for the prevention of cardiovascular disease and cognitive impairment. BMJ Open. 2016 Jun 10;6(6):e010806

Mangialasche F, Baglioni M, Cecchetti R, Kivipelto M, Ruggiero C, Piobbico D, Kussmaul L, Monastero R, Brancorsini S, Mecocci P. Lymphocytic mitochondrial aconitase activity is reduced in Alzheimer’s disease and mild cognitive impairment. J Alzheimers Dis. 2015;44(2):649-60.

Santoni G, Angleman S, Welmer AK, Mangialasche F, Marengoni A, Fratiglioni L. Age-related variation in health status after age 60. PLoS One. 2015 Mar 3;10(3):e0120077.

Ngandu T, Lehtisalo J, Solomon A, Levälahti E, Ahtiluoto S, Antikainen R, Bäckman L, Hänninen T, Jula A, Laatikainen T, Lindström J, Mangialasche F, Paajanen T, Pajala S, Peltonen M, Rauramaa R, Stigsdotter-Neely A, Strandberg T,  Tuomilehto J, Soininen H, Kivipelto M. A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial. Lancet. 2015 Jun 6;385(9984):2255-63

Mangialasche F, Westman E, Kivipelto M, Muehlboeck JS, Cecchetti R, Baglioni  M, Tarducci R, Gobbi G, Floridi P, Soininen H, Kłoszewska I, Tsolaki M, Vellas B, Spenger C, Lovestone S, Wahlund LO, Simmons A, Mecocci P; AddNeuroMed consortium. Classification and prediction of clinical diagnosis of Alzheimer’s disease based  on MRI and plasma measures of α-/γ-tocotrienols and γ-tocopherol. J Intern Med. 2013 Jun;273(6):602-21.

Mangialasche F, Xu W, Kivipelto M, Costanzi E, Ercolani S, Pigliautile M,Cecchetti R, Baglioni M, Simmons A, Soininen H, Tsolaki M, Kloszewska I, Vellas B, Lovestone S, Mecocci P; AddNeuroMed Consortium. Tocopherols and tocotrienols plasma levels are associated with cognitive impairment. Neurobiol Aging. 2012, 33(10):2282-90.

Mangialasche F, Kivipelto M, Mecocci P, Rizzuto D, Palmer K, Winblad B, Fratiglioni L. High plasma levels of vitamin E forms and reduced Alzheimer’s disease risk in advanced age. J Alzheimers Dis 2010;20(4):1029-37.

Mangialasche F, Solomon A, Winblad B, Mecocci P, Kivipelto M. Alzheimer’s disease: clinical trials and drug development. Lancet Neurology 2010;9(7):702-16.

Mangialasche F, Polidori MC, Monastero R, Ercolani S, Camarda C, Cecchetti R, Mecocci P. Biomarkers of oxidative and nitrosative damage in Alzheimer’s disease and mild cognitive impairment. Ageing Res Rev. 2009;8(4):285-305.

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