People’s individual cognitive capabilities differ, and differences widen as people age. At ARC, we focus on understanding the reasons for these differences. Why do some 80-year-olds have better memories than 35-year-olds? Why do some people maintain a youthful brain but others develop dementia? How does behavior over the life course affect brain changes? Is it possible to slow, stop, or reverse cognitive decline by mental and/or physical training?
Several factors typically interact to cause faster cognitive decline and dementia, and some factors can protect against disease. We use SNAC-K and other large databases to study the impact of multiple factors. Collaborating in the CAIDE and HARMONY studies enables us to investigate how risks accumulate over the entire life course. Our research focuses on vascular factors like diabetes, hypertension, and obesity; lifestyle factors like diet, smoking, alcohol use, and leisure activities; and genetic factors.
ARC also participates in FINGER, one of the first intervention studies attempting to postpone dementia by modifying a wide range of risk factors at the same time.
Additional research in the field of brain aging not listed below is underway at the af Jochnick Center for the Cognitive Neuroscience of Aging.
- Brain functional connectome across the human lifespan: links to white matter degeneration, dopamine depletion, and cognitive decline (PI: Alireza Salami, firstname.lastname@example.org)
- Cognitive fatigue in aging: psychological and neurobiological mechanisms (PI: Jonas Persson, email@example.com)
- CoSTREAM: A multidisciplinary approach to understand the link between stroke and Alzheimer’s (PI of the Swedish work package: Laura Fratiglioni, firstname.lastname@example.org)
- Dopamine and behavioral control across the adult lifespan (PI: Marc Guitart-Masip, email@example.com)
- Early detection of dementia: finding the best combination of cognitive and non-cognitive markers of preclinical dementia (PI: Erika Jonsson Laukka, firstname.lastname@example.org)
- IronAge (PI: Gregoria Kalpouzos, email@example.com)
- Mapping and intervening with the behavioral factors influencing cognitive aging (PI: Martin Lövdén, firstname.lastname@example.org)
- Multimodal strategies to promote a healthy brain in aging: innovative evidence-based tools (MULTI-MODE) (PI: Miia Kivipelto, email@example.com)
- Neurocognitive fatigue, restoration, and resilience—effects of natural vs. urban environments (PI: Cecilia Stenfors, firstname.lastname@example.org)
- Not all older adults develop dementia: exploring underlying compensatory mechanisms related to healthy brain aging (PI: Laura Fratiglioni, email@example.com)
- Releasing the brakes on adult plasticity (REBOOT) (PI: Martin Lövdén, firstname.lastname@example.org)
- Structure and volume of the olfactory brain: relationships to olfactory dysfunction, cognitive decline, and prospective dementia (PI: Erika Laukka, email@example.com)
- Temporal dynamics of adult brain plasticity: effects of motor learning on brain anatomy and cognitive functions in adulthood (PI: Claudio Brozzoli, Claudio.Brozzoli@ki.se)
- The body-mind connection: exploring the biological mechanisms underlying the effects of somatic health on brain aging (PI: Laura Fratiglioni, firstname.lastname@example.org)
- The relation between dopamine-regulating genes, neurocognition, and aging (PI: Jonas Persson, email@example.com)
- The role of cerebral small vessel disease in cognitive aging (PI: Qiu, Chengxuan, firstname.lastname@example.org)